• Knowledgebase: Fever Questions

    Answers to Questions about fevers.

    2. How do you alternate Tylenol with Advil? - Top

    Many people (often on the recommendation of their doctor) treat high fevers by alternating Tylenol (acetaminophen) with Advil (ibuprophen). There are no good studies that I am aware of that document the safety nor the improved effectiveness of this treatment over one of the drugs alone. It is usually given such that each medicine is given on a six hour dosing schedule, therefore one or the other is given every three hours. - Updated: May 13, 2001

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    • James L Horwitz, MD

    David C. Thomas, MD

    Barbara Lindberg, PNP